青春期和早期成年期的体力活动和40岁之前的乳腺癌风险 40岁
Rebecca D Kehm1, Jeanine M Genkinger1,2, Julia A Knight3,4
1Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
概括
青春期和早期成年期的娱乐性体育活动与40岁之前患乳腺癌的风险较低有关. 在年轻女性中促进体育活动可能有助于减少乳腺癌发病率.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 40岁以下女性乳腺癌发病率的增加需要对这一人口群体的风险因素进行研究.
- 了解可修改的风险因素对于早期预防策略至关重要.
研究的目的:
- 调查青春期和成年早期的娱乐性体力活动 (RPA) 与40岁前乳腺癌风险之间的关联.
- 确定早期乳腺癌的潜在预防措施.
主要方法:
- 利用了26,348个人的国际家庭队列,其中包括2,502名40岁前患有乳腺癌的女性.
- 在青春期 (12-17岁) 和早期成年期 (25-34岁) 评估RPA水平 (中度和强度),使用自我报告的时间.
- 采用Cox比例危险回归模型来分析RPA四分位数与乳腺癌风险之间的关系,直到40岁.
主要成果:
- 青春期RPA的最高四分位数与12%的乳腺癌风险降低有关 (HR:0.88,95%CI:0.78-0.98).
- 成年早期RPA的最高四分位数与16%的乳腺癌风险降低有关 (HR:0.84,95%CI:0.74-0.95).
- 与没有RPA相比,在这两个时期参与高RPA的风险降低了22% (HR:0.78,95%CI:0.68-0.89).
结论:
- 在成长时期 (青春期和成年早期) 进行娱乐性体力活动可能会显著降低40岁前患乳腺癌的风险.
- 研究结果支持实施鼓励年轻人体育活动的政策,以打击乳腺癌发病率的上升.
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