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在长期的Covid中,脑代谢连接的持续功能障碍与认知症状

Anna Lisa Martini¹, Giulia Carli², Silvia Paola Caminiti³

¹Nuclear Medicine Unit, Department of Diagnostic Imaging, N.O.P. - S. Stefano, U.S.L. Toscana Centro, Prato, Italy.

European journal of nuclear medicine and molecular imaging

|October 15, 2024

概括

长期COVID幸存者显示大脑连接的改变. 最初,执行和注意网络是超连接的,但后来变得低连接,这可能解释了这些患者持续的神经症状.

科学领域:

神经科学是一个神经科学.
传染性疾病传染性疾病
医疗成像医学成像

背景情况:

长期COVID与持续的神经症状有关.
大脑代谢连接的改变可能是这些症状的基础.
了解这些变化对于有效的患者管理至关重要.

研究的目的:

通过不同恢复阶段检查SARS-CoV-2幸存者的大脑代谢连接.
阐明长期COVID中持续的神经症状背后的机制.
为了比较神经COVID患者与健康对照者的代谢连接性.

主要方法:

44名患有神经症状的患者的横截面研究.
使用FDG-PET扫描来评估大脑的葡萄糖代谢.
区域间相关性分析 (IRCA) 评估了静止状态网络 (ADMN,PDMN,EXN,ATTN,LIN,ASN) 中的代谢连接性.

主要成果:

急性/次急性阶段在执行 (EXN) 和注意 (ATTN) 网络中显示出超连接性.
慢性阶段在EXN和ATTN中表现出低连接性,与认知缺陷相关.
在急性阶段观察到前岛皮层的低代谢,随着时间的推移而消失.

结论:

在早期阶段EXN和ATTN的补偿性超连接性在长期内转向低连接性.
在没有低代谢的情况下,前额网络的低连接性可能解释了长期COVID中长期的神经症状.
大脑代谢连接分析提供了关于神经COVID病理生理学的见解.

关键词:

大脑代谢连接性大脑代谢连接性德国联邦财政部-PET 长时间的COVID.神经COVID是一种神经-COVID.休息状态网络的静止状态.

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