溶解性尿激活白细胞细胞粘附分子是狼性炎的强烈预测因素
Dalena Chu1, Noa Schwartz2, Jeanette Ampudia1
1Equillium, La Jolla, CA, USA.
Rheumatology (Oxford, England)
|October 15, 2024
概括
尿激活白细胞细胞粘附分子 (ALCAM) 可以预测狼性炎 (LN) 的进展和治疗反应. 这种生物标志物对随着时间的推移监测疾病活动和患者的结果有希望.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 狼性炎 (LN) 是系统性红斑狼的一种严重并发症.
- 对LN进展和治疗反应的预测生物标志物对于有效的患者管理至关重要.
研究的目的:
- 评估尿激活白细胞细胞粘附分子 (ALCAM) 和CD6作为LN进展或疾病解决的预测因素.
- 在1年的前性研究中评估这些尿路生物标志物的实用性.
主要方法:
- 预期收集1年内从122名经过活检证明的LN患者的血清和尿液样本.
- 测量可溶性ALCAM和CD6水平,将其正常化为尿液中的肌素.
- 对生物标志物水平与疾病指标的横截面和纵向分析.
主要成果:
- 尿液ALCAM与关键的LN疾病指标相关,包括尿蛋白肌素比率,脏SLEDAI和医生全球评估.
- 尿液ALCAM显示LN的高预测值 (AUC0.97),表现优于尿液CD6 (AUC0.71).
- 在3个月内尿液ALCAM水平的变化使1年后的响应者与不响应者区别开来.
结论:
- 尿路ALCAM反映了LN活动的变化.
- 尿液ALCAM显示了作为LN患者治疗反应的预测生物标志物的潜力.
相关概念视频
Selectins
3.3K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.3K
Nephrotic Syndrome II : Assessment and Medical Management
2
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
2


