在患有Dupilumab治疗的鼻息肉的慢性鼻炎患者中,因改善嗅觉而导致的体重变化
Cecilia Rosso1,2, Eugenio De Corso3, Anastasia Urbanelli4
1Otorhinolaryngology Unit, ASST Santi Paolo e Carlo, Università degli Studi di Milano, Milan, Italy. rosso.cecilia1@gmail.com.
概括
治疗慢性鼻炎与鼻多重症 (CRSwNP) 的dupilumab治疗显著改善了嗅觉,并导致体重增加. 嗅觉改善的患者体验到显著的BMI增加,这表明更好的嗅觉和体重变化之间存在联系.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 代谢医学是一种代谢医学.
背景情况:
- 生物疗法,包括Dupilumab,已经彻底改变了CRSwNP治疗.
- 了解与治疗相关的副作用和相关性对于患者管理至关重要.
研究的目的:
- 为了研究用Dupilumab治疗的CRSwNP患者的体重变化.
- 探索这些患者的嗅觉改善和体重增加之间的相关性.
主要方法:
- 对96名CRSwNP患者进行了回顾性多中心研究.
- 12个月的随访评估BMI,嗅觉功能和疾病严重程度.
主要成果:
- 杜皮卢马布治疗显著增加了BMI和嗅觉感知 (p < .001).
- 嗅觉有所改善的患者 (从低血到正常血) 显著增加体重 (p < .001).
- 气喘或稳定/恶化的嗅觉与显著的BMI变化没有相关性.
结论:
- 用Dupilumab改善嗅觉与体重增加/BMI增加相关.
- 其他因素,如改善鼻腔气流和减少皮质类固醇使用,可能会影响体重.
- 需要进一步的研究来确定对体重调节的因果关系和长期影响.
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