口语流利指数 (VFI) 在肌缩侧面硬化症的临床有用性
Edoardo Nicolò Aiello1, Beatrice Curti1, Silvia Torre1
1Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy.
概括
语言流指数 (VFI) 提供了比传统的单词数量更准确的评估,比传统的单词数量更准确的评估,通过最大限度地减少运动语音障碍的影响,对肌缩侧硬化症 (ALS) 患者的执行功能进行评估.
科学领域:
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 肌缩侧面硬化症 (ALS) 可以影响认知功能,包括执行能力.
- 评估ALS患者的执行功能对于临床管理至关重要.
- 传统的口语流测试可能会被影响语音生产的运动缺陷所混.
研究的目的:
- 为了评估口语流利指数 (VFI) 与标准语音口语流利测试相比的临床实用性.
- 为了确定VFI是否更好地反映意大利语ALS患者的执行地位.
主要方法:
- 343名非痴呆性ALS患者和226名健康对照 (HCs) 完成了爱丁堡认知和行为ALS查 (ECAS) 语言流利 - S任务.
- 语言流利度 (产生的单词数 - NoW,大声阅读单词的时间 - TRW,VFI) 与ALS功能评分表 - 修订 (ALSFRS-R) 和ECAS-执行分数相关.
- 意大利对NoW和VFI的规范是在HC中建立的.
主要成果:
- VFI,但不是NoW或TRW,与ALSFRS-R气柱/呼吸系统得分相关.
- VFI和NoW都与ECAS-Executive分数相关 (p < .001),而TRW则没有.
- VFI发现的执行障碍患者比NoW (31.1%) 较少 (26.8%),这表明特异性更高.
- 与正常VFI和NoW分数患者相比,受损VFI分数的患者表现出较差的执行功能.
结论:
- 意大利VFI是评估ALS患者执行状态的有效工具.
- VFI有效地减轻了运动语言障碍对认知评估的影响.
- 在ALS的背景下,VFI为执行职能提供了更精细的衡量标准.
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