相关实验视频

Updated: Jun 10, 2025

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

产前皮质类固醇用于晚期小到妊娠年龄的胎儿

Inshirah Sgayer^1,2, Sondos Hassan¹, Talal Sarhan¹

¹Department of Obstetrics and Gynecology, 61255 Galilee Medical Center , Nahariya, Israel.

Journal of perinatal medicine

|October 15, 2024

概括

产前皮质类固醇 (ACS) 并没有减少晚期早产婴儿的新生儿发病率,这些婴儿的胎儿小于妊娠年龄. 暴露和未暴露组之间的呼吸困难和其他并发症的发生率仍然相似,在初级复合结果中没有显著差异.

科学领域:

产科和妇科产科和妇科
新生儿科学新生儿科学
周围生理学周围生理学

背景情况:

晚期早产婴儿 (34-36周) 怀孕年龄小 (SGA) 胎儿的新生儿发病风险增加.
产前皮质类固醇 (ACS) 通常用于促进胎儿肺成熟,但它们在这个妊娠窗口内的SGA胎儿的有效性仍在争论中.

研究的目的:

评估产前皮质类固醇 (ACS) 对晚期早产妊娠中新生儿发病率的影响,后期早产妊娠中小于妊娠年龄 (SGA) 胎儿所造成的并发症.
为了比较SGA暴露和未暴露于ACS的胎儿之间的综合新生儿结局.

主要方法:

在妊娠34+0周至36+6周之间分娩的生长受限胎儿的回顾性研究.
主要综合结局包括呼吸支,呼吸困难综合征,短暂的呼吸暂停,支气管肺功能失调,死性肠球炎,腹腔内出血和新生儿死亡率.
多变量分析调整为妊娠糖尿病和分娩方式.

主要成果:

主要组合结局在暴露于ACS和未暴露组之间是相似的 (26.1%对20.8%,p=0.512).
在暴露于ACS的新生儿中,低血糖更频繁 (37.0%对19.5%,p=0.037).
剖腹产与主要结局的风险增加有关 (OR=2.13,p=0.013).

结论:

产前皮质类固醇 (ACS) 没有显示出对晚期早产婴儿的新生儿发病率有显著的降低,这些婴儿的胎儿对于妊娠年龄来说很小.
可能需要进一步的研究来确定可能受益于ACS的特定子组.
这些发现表明,在这个人群中常规使用ACS可能不会改善新生儿整体结果.

关键词:

在产前使用皮质类固醇.在晚期的早产期.时间过早的早产.呼吸困扰综合征是呼吸困扰综合征.对于怀孕年龄来说小的

更多相关视频

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...