在一般人群中,功能性可巴胺缺乏症的患病率和相关的死亡风险:与可巴胺缺乏症不同的一种被忽视的表型
Yan Liu1,2,3, Yi Gao3, Yige Liu1,2
1Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Journal of the American Nutrition Association
|October 15, 2024
概括
功能性可巴胺 (Cbl) 缺乏症,定义为Cbl和甲基马龙酸水平升高,影响4.5%的美国成年人,并显著增加死亡风险. 与Cbl缺乏症不同,功能性Cbl缺乏症不会通过Cbl补充剂减轻.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 老年学是一门学科.
背景情况:
- 目前的指导方针不足以解决功能性可巴胺 (Cbl) 缺乏症,一种降低Cbl敏感性的状态.
- 这项研究调查了美国成年人功能性Cbl缺乏症的患病率和死亡率相关性.
研究的目的:
- 为了确定功能性Cbl缺乏在美国成年人群中的患病率.
- 为了比较与功能性Cbl缺乏与Cbl缺乏相关的死亡风险.
主要方法:
- 从1999年至2014年,对22513名美国成年人 (年龄≥20岁) 进行了队列研究,后续研究持续到2019年.
- 功能性Cbl缺乏症定义为甲基马龙酸 (MMA) 和Cbl水平升高 (MMA>250nmol/L,Cbl>400pg/mL).
- 血清Cbl缺乏症定义为血清Cbl<148 pmol/L (200 pg/mL). 血清Cbl缺乏症是指血清Cbl低于148 pmol/L (200 pg/mL) 的血清Cbl.
主要成果:
- 功能性Cbl缺乏症的流行率为4.5% (约. 10百万成年人),相比之下,Cbl缺乏的比例为2.1%.
- 功能性Cbl缺乏组 (MMAhighCblhigh) 与MMAlowCbllow组相比,显示出明显更高的全因 (HR 1.76) 和心血管死亡率 (HR 2.17).
- 与Cbl缺乏相关的死亡风险在混调整后并不显著.
结论:
- 功能性Cbl缺乏症比Cbl缺乏症更为普遍,并带来显著的死亡风险.
- 补充Cbl或增加摄入量似乎没有降低功能Cbl缺乏症的患病率或死亡风险.
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