针对治疗耐药抑郁症的基于正念认知疗法:系统审查和元分析的协议
Michele F Rodrigues1, Larissa Junkes1, Jose Appolinario1
1Treatment Resistant Depression Group-Institute of Psychiatry from the Federal University of Rio de Janeiro (IPUB-UFRJ), Rio de Janeiro, Brazil.
PloS one
|October 15, 2024
概括
本系统性审查审查了针对治疗耐药抑郁症 (TRD) 的基于正念认知疗法 (MBCT). 它评估了MBCT.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 基于证据的医学基于证据的医学.
- 认知行为疗法 认知行为疗法
背景情况:
- 大型抑郁症 (MDD) 影响全球数以百万计的人,其中大量人患有耐治疗抑郁症 (TRD).
- TRD的定义是对标准抗抑郁药物药物和疗法的不充分反应.
- 基于正念的认知疗法 (MBCT) 被探索为TRD的潜在干预措施.
研究的目的:
- 系统地审查MBCT在减少TRD成年人的抑郁症状的有效性.
- 评估MBCT的安全性和耐受性概况,与标准护理或TRD的其他活性治疗相比.
- 综合来自随机临床试验和准实验研究的证据.
主要方法:
- 在主要数据库 (MEDLINE,Embase,PsycINFO,Web of Science) 和临床试验网站 (ClinicalTrials.gov.gov) 中进行全面的文献搜索.
- 包括随机临床试验和准实验性研究,并对参考清单进行手动选.
- 使用Cochrane风险偏见工具 (RoB2) 进行质量评估,并通过GRADE方法进行证据评估.
主要成果:
- 在系统性审查完成后,该部分将被填写.
- 该审查将将MBCT的疗效与标准护理和其他活性治疗进行比较.
- 将分析TRD人群中MBCT的安全性和耐受性数据.
结论:
- 这一系统性审查将为MBCT对治疗耐药抑郁症患者的作用提供关键的见解.
- 这些发现将为临床实践和未来的研究方向提供信息,以管理耐火抑郁症.
- 这项研究旨在确定MBCT是否为TRD提供可行的替代或辅助疗法.
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