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Updated: Jun 10, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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在细胞状态过渡过程中,UBR-5和UBE2D通过破坏多A结合蛋白PABP-2的稳定性来调节来自茎命运的及时退出

Jose Francisco Calva Moreno1, George Jose1, Yi M Weaver1

  • 1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proceedings of the National Academy of Sciences of the United States of America
|October 15, 2024
PubMed
概括

在动物中,UBR-5 E3结合酶控制干细胞命运过渡. 它与LET-70一起工作以退出干细胞,对抗PABP-2以确保适当的细胞分化和发育.

关键词:
在HECT E3结合酶中.老化的老化 衰老的老化聚A结合蛋白质是多A结合蛋白质的组成部分.蛋白质稳定症是一种蛋白质稳定症.根源的命运 根源的命运

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