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Updated: Jun 10, 2025

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第一个类型的小分子降解孕妇X受体增强化疗效

Andrew D Huber1, Young-Hwan Jung1, Yongtao Li1

  • 1Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 1000, Memphis, Tennessee 38105-3678, United States.

Journal of medicinal chemistry
|October 15, 2024
PubMed
概括

研究人员设计了新型分子来降解Pregnane X受体 (PXR),这是一种对药物的有效性和安全性产生负面影响的蛋白质. 这种PXR降解方法提高了化疗的有效性,并为药物开发提供了新的策略.

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