孕产妇糖尿病和心脏左室结构和功能在婴儿:哥本哈根婴儿心脏研究
Jonas Ghouse1,2,3, Magdalena Hansson4, Ruth Ottilia B Vøgg3,4
1Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Diabetes care
|October 15, 2024
概括
怀孕期间的孕产妇糖尿病,包括先前存在的糖尿病和妊娠期糖尿病 (GDM),与婴儿心脏结构和功能的微妙变化有关,影响左心室 (LV) 的尺寸和性能.
科学领域:
- 心脏病学 心脏病学
- 新生儿科学 新生儿科学
- 内分泌学 在内分泌学.
背景情况:
- 孕产妇糖尿病是众所周知的子女先天性心脏缺陷的风险因素.
- 暴露于母亲糖尿病的婴儿的微妙心脏变化需要进一步调查.
研究的目的:
- 为了评估母亲先前存在的糖尿病和妊娠期糖尿病 (GDM) 和婴儿心脏结构和功能参数之间的关联.
- 在暴露于母亲糖尿病的新生儿中识别特定的左心室 (LV) 变化.
主要方法:
- 一项对25486名婴儿进行的队列研究,这些婴儿在出生后60天内接受了心声扫描.
- 线性回归分析用于比较患有糖尿病和没有糖尿病的母亲的婴儿之间的LV参数.
- 评估包括LV后壁厚度,内径,中风体积,心率和中枢的速度.
主要成果:
- 暴露于母亲先前存在的糖尿病的婴儿表现出更厚的LV后壁,更小的LV内部直径,减少中风体积,心率增加和更高的中枢早期峰值速度.
- 暴露于GDM的婴儿与暴露于先前存在的糖尿病的婴儿相比,表现出更小的LV内部直径和类似的,但不那么明显的心脏变化.
- 第三季度较高的HbA1c水平与特定的LV变化和心率变化相关.
结论:
- 母亲先前存在的糖尿病与婴儿左心室 (LV) 结构和功能的显著改变有关.
- 孕期糖尿病 (GDM) 也与婴儿心脏变化有关,尽管程度较小.
- 这些发现强调了母亲的血糖控制对胎儿心脏发育的影响.
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