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Updated: Jul 11, 2026

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对SARS-CoV-2受体结合域突变体的高通量分子模拟量化了动态波动和蛋白质表达之间的相关性

Victor Ovchinnikov1, Martin Karplus1,2

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

Journal of computational chemistry
|October 15, 2024
PubMed
概括

来自分子动力学模拟的蛋白质灵活性显示了与SARS-CoV-2受体结合域 (RBD) 突变表达的温和联系. 机器学习模型提供更好的预测,但需要广泛的突变数据进行训练.

关键词:
冠状病毒冠状病毒病毒深度突变扫描 (deep mutational scanning) 是一种对突变进行深度扫描的方法.线性回归是一种线性回归.分子动力学分子动力学

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Protein Dynamics in Living Cells01:19

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Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...