口服分解膜 (ODF) 配方的口味掩蔽研究,含有孟坦丁化
Ganesan Gobal1, Hiu Ching Phang1, Zhi Qi Ng1
1University of Cyberjaya, Selangor, Malaysia.
International journal of pharmaceutical compounding
|October 15, 2024
概括
这项研究开发了一种口服分解薄膜 (ODF) 用于记忆素化物,改善老年和阿尔茨海默病患者的药物坚持. 配方M7含30mg阿斯巴甜有效地掩盖了苦味,创造了一个更容易消费的剂量形式.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 老年医学 老年医学
背景情况:
- 老年患者,特别是患有阿尔茨海默氏症的患者,由于药物管理的复杂性和吞困难,他们面临药物遵守方面的挑战.
- 梅曼丁化是阿尔茨海默氏症的关键药物,具有苦味,这阻碍了其在口服分解薄膜 (ODF) 等患者友好的剂型中配制.
研究的目的:
- 开发和优化一种口服分解膜 (ODF) 的美曼丁化水.
- 为了评估开发的孟坦丁化ODF的口感和关键药物特性.
主要方法:
- 孟曼丁化ODF使用溶剂造方法,然后经过冷干燥制备.
- 配方使用了瓜尔,PEG 400和小麦粉,含有不同度的阿斯巴甜或阿苏K来掩盖味道.
- 评估的参数包括抗拉强度,分解时间,厚度,溶解,药物含量和可口性.
主要成果:
- 配方M7,包含30毫克的阿斯巴甜,被确定为最佳的口味掩盖的ODF.
- 开发的ODF表现出可接受的物理特性:拉力强度为0.03kPa,折叠耐力为351次翻转,厚度为0.94毫米,分解时间为34.15秒.
- 30毫克的阿斯巴甜证明足以掩盖ODF中孟坦丁化的苦味.
结论:
- 开发出了一种成功的口味掩盖的孟坦丁化ODF (20x20毫米),增强了老年患者的口感和易于消费.
- 这种ODF配方为改善阿尔茨海默病患者的药物服药能力提供了一个有希望的替代方案.
- 这项研究强调了阿斯巴甜在ODF应用中掩盖味道的记忆素化物中的有效性.
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