和多醇基物质 (PFAS) 加快通过增加的C-反应蛋白调解生物衰老
Zongxi Zhao1, Jiayan Zhou2, Anye Shi3
1Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, United Kingdom.
Journal of hazardous materials
|October 15, 2024
概括
暴露于Per和多基基物质 (PFAS) 显著加快生物衰老,增加疾病风险. 这项研究没有发现PFAS的安全暴露值,强调了需要采取公共卫生行动的必要性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 老年学是一门学科.
背景情况:
- 不健康的生物衰老与与年龄相关的疾病和死亡率的增加有关.
- 以前的研究表明Per-和多基基物质 (PFAS) 与生物衰老之间存在联系,但缺乏详细的暴露-反应和调解分析.
研究的目的:
- 为了研究血清PFAS水平与美国大量成年人群的生物衰老之间的关联.
- 探索暴露-反应关系,效果修饰剂和PFAS暴露和生物衰老的媒介.
主要方法:
- 从NHANES (2003-2018) 中对14865名美国成年人的横截面分析.
- 测量了四种 PFAS 的血清度:PFOA,PFOS,PFNA 和 PFHxS.
- 利用了通用线性模型,立方线模型,加权总和回归和调解分析.
主要成果:
- 较高的血清PFAS水平与加速的生物衰老有关.
- 特定的PFAS显示了显著的关联:PFOA (3.3年),PFOS (14.9年),PFNA (10.9年) 和PFHxS (8.8年) 的衰老加速.
- 没有确定PFAS的安全暴露值;PFOA是主要的贡献者,C-反应蛋白可能会调解衰老效应.
结论:
- 暴露于PFAS与显著加速生物衰老有关.
- 这些发现强调了PFAS对公共健康的关注,以及需要采取干预措施来减轻它们对健康衰老的影响.
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