精神分裂症,临床和基础研究在NIMH:一个75年的回顾
E Fuller Torrey1, Wendy Simmons1, Lisa Dailey2
1The Stanley Medical Research Institute.
Psychiatry research
|October 15, 2024
概括
国家心理健康研究所 (NIMH) 已大幅减少对精神分裂症等严重精神疾病的临床研究的资金. 建议包括重建临床研究作为优先事项.
科学领域:
- 心理健康研究 心理健康研究
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 国家心理健康研究所 (NIMH) 成立于1949年,被授权研究严重精神疾病.
- 精神分裂症单独占医院病床的很大一部分,突出了研究的必要性.
- 该研究所将于2024年庆祝75周年,这促使该研究所对其研究优先事项进行审查.
研究的目的:
- 评估NIMH资助的临床和基础研究之间的历史平衡.
- 用精神分裂症作为案例研究来评估NIMH资助的研究的相对重要性.
- 为了识别NIMH研究组合的趋势随着时间的推移.
主要方法:
- 分析已发表的研究和NIMH记录.
- 与现任和前任NIMH员工的采访.
- 研究资助时期的比较分析 (例如,1984-1988年与2018-2022年).
主要成果:
- 在最初的40年里,NIMH最初平等地资助临床和基础研究.
- 20世纪90年代发生了对基础研究的转变,受到像人类基因组项目这样的项目的影响.
- 到2015年,临床研究仅占NIMH投资组合的10%,在2006-2023年期间,精神分裂症和双相情感障碍的外围药物试验下降了95%.
结论:
- 数据表明,NIMH在三十年来对严重精神疾病的临床研究下降了至少90%.
- 美国国家精神卫生研究所 (NIMH) 应重视重症精神疾病的临床研究,并与其最初的国会授权保持一致.
- 建议NIMH将至少50%的与疾病相关的研究资金用于临床研究,并提供透明的文件.
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