偏头痛可能是视网膜中风的独立风险因素:基于人口的队列研究
Jay B Lusk1, Ailin Song2, Shakthi Unnithan3
1Department of Neurology, Duke University School of Medicine, Durham, North Carolina.
Clinical neurology and neurosurgery
|October 15, 2024
概括
偏头痛与视网膜中枢动脉封闭 (CRAO) 作为主要诊断并不相关. 然而,更广泛的定义表明了潜在的关联,需要进一步调查偏头痛和视网膜中风风险.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 偏头痛是脑缺血性中风的已知危险因素,特别是在偏头痛与光环的患者中.
- 偏头痛和视网膜中风 (中央或分支视网膜动脉封闭;CRAO或BRAO) 之间的关联仍然不清楚.
研究的目的:
- 调查医院记录的偏头痛与视网膜中风风险之间的关联.
- 确定偏头痛是否是中央视网膜动脉封闭 (CRAO) 和分支视网膜动脉封闭 (BRAO) 的危险因素.
主要方法:
- 这是一项回顾性,观察性,队列研究,使用来自纽约,加利福尼亚和佛罗里达州 (2003-2015) 的基于人口的数据.
- 暴露:医院记录的偏头痛. 在医院记录的偏头痛. 终点:医院记录的CRAO,BRAO,以及任何视网膜动脉封闭 (RAO).
- 用特定原因的危险模型来分析这种联系.
主要成果:
- 这项研究包括超过3900万名患者;110万有记录的偏头痛.
- 当偏头痛被列为主要诊断时,它与CRAO没有关联 (aHR 1.15).
- 在考虑任何诊断位置时,偏头痛与CRAO相关 (aHR为1.39),并且证实了以前与脑缺血性中风的相关性.
结论:
- 在一项基于索赔的大型美国研究中,在偏头痛和CRAO之间没有发现显著的关联作为主要诊断.
- 当使用更广泛的定义时,出现了偏头痛和CRAO之间的潜在关联,这表明了未来研究的途径.
- 建议使用门诊和药房声明进行进一步的研究,以探索偏头痛与视网膜中风的联系.
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