具有可编程药物释放的抗微生物药物的氧反应降解,以增强抗菌活性
Yue Zhang1, Xuehan Yang1, Yawei Zhao1
1Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Colloids and surfaces. B, Biointerfaces
|October 15, 2024
概括
研究人员开发了与半孔有机二氧化 (Ag-MON@TOB (Se)) 集成的新型银纳米粒子,用于向的抗生素输送. 该系统提供可编程的药物释放,增强了对细菌感染的治疗,提高了生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 传染病研究 传染病研究
背景情况:
- 抗生素耐药性需要针对细菌感染的先进药物输送系统.
- 实现高生物相容性和有针对性的抗微生物药物输送仍然是一个重大挑战.
- 在感染地点开发可编程抗微生物释放系统至关重要.
研究的目的:
- 用于制造与disenide桥接的半孔有机纳米颗粒支的银纳米颗粒 (Ag NPs),用于配送托布拉米辛 (TOB).
- 创建一个纳米载体 (Ag-MON@TOB (Se)) 具有很高的药物载荷能力和生物相容性.
- 研究感染微环境中由氧化刺激触发的可编程药物释放.
主要方法:
- 合成与disenide桥接的半孔有机纳米颗粒支持的银纳米颗粒 (Ag NPs).
- 在纳米载体系统中装载托布拉米 (TOB) (Ag-MON@TOB (Se)).
- 评估生物相容性,在生理条件下的稳定性和药物释放动力学,以应对氧化刺激.
- 与氧化稳定的对应物相比,对抗菌疗效的体外和体内评估 (Ag-MON@TOB (S)).
主要成果:
- 制造的Ag-MON@TOB (Se) 显示出良好的生物相容性和高稳定性.
- 纳米载体表现出可编程的结构不稳定,触发了对氧化应激反应的连续药物释放.
- 与Ag-MON@TOB (S) 相比,Ag-MON@TOB (Se) 在体外和体内显著增强了抗菌疗法.
结论:
- 脱化物桥接纳米载体为可编程药物释放提供了一个有希望的战略.
- 响应性可降解车辆可以增强对细菌感染的治疗.
- 这种方法有可能改善抗生素耐药性防治的结果.
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