精神分裂症第一期抗精神病素素患者的改变大脑复杂性:一个全脑voxel-wise研究
Naici Liu1, Rebekka Lencer2, Christina Andreou3
1Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
NeuroImage. Clinical
|October 15, 2024
概括
精神分裂症与减少大脑复杂性和改变皮质折叠有关,特别是在早期阶段. 非线性动态分析显示,与健康个体相比,患者的大脑复杂性指标普遍下降.
科学领域:
- 神经成像是一种神经成像.
- 计算神经科学是一种神经科学.
- 精神病学是一个精神病学.
背景情况:
- 皮层拓学是大规模大脑网络的特征,但传统的ROI方法将分析局限于线性相互作用.
- 大脑的复杂性本质上是非线性的,需要先进的模型来准确表征.
- 使用非线性动态的voxel级分析可以揭示大脑区域和皮质折叠的拓复杂性.
研究的目的:
- 为了研究第一期抗精神病原始精神分裂症 (FES) 患者大脑结构复杂性的变化.
- 应用一个非线性动态模型来描述在voxel层面上的拓复杂性.
- 探索大脑复杂度测量和早期精神分裂症之间的关系.
主要方法:
- 分析了150名FES患者和161名健康对照 (HC) 的T1加权MRI数据.
- 混沌分析,使用最大的Lyapunov指数 (Lambda),量化大脑结构复杂性.
- 莫莱特波纹相关性在频域中映射了兰巴达空间序列,以评估皮层折叠的复杂性.
主要成果:
- 在FES患者中,Lambda值在前额,额头,,,边缘,基底,乳头和小脑区域普遍下降.
- 这些发现表明,在早期精神分裂症中,大脑拓复杂性和皮质折叠的普遍丧失.
- 特定地区的Lambda值增加表明复杂性重新分配,可能随着疾病的进展而进展. 未经治疗的精神病持续时间与小脑,关节和关节回转的兰巴达值相关.
结论:
- 非线性动态分析为识别早期精神分裂症中结构性大脑改变提供了一种新的方法.
- 大脑复杂性测量,特别是使用最大的利亚普诺夫指数,对精神分裂症的早期变化很敏感.
- 这种方法有可能改善对精神分裂症中结构性大脑异常的理解和诊断.
相关概念视频
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
489
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
489
Biological Causes of Schizophrenia
46
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
46
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
68
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
68
Schizophrenia
70
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
70
Psychological and Sociocultural Causes of Schizophrenia
80
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
80
Negative and Cognitive Symptoms of Schizophrenia
44
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
44


