脑下垂体缩和结构共变性在记忆缓和认知障碍和阿尔茨海默氏症痴呆症中
Hannah Pecher1, Melanie Storch2, Frauke Beyer3
1Department of Neurology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), German; Department of Radiology, Bundeswehrkrankenhaus Berlin, Scharnhorststr. 13, 10115 Berlin, Germany.
NeuroImage. Clinical
|October 15, 2024
概括
脑下垂体缩是阿尔茨海默病 (AD) 的早期指标,即使在轻度认知障碍中也是如此. 脑下垂体体积损失与AD患者对记忆和自主调节至关重要的脑部区域的损伤相关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 阿尔茨海默病 (AD) 涉及渐进的认知衰退和大脑缩,通常在中间叶.
- 在阿尔茨海默病中,影响新陈代谢和自主功能的下丘脑参与尚未得到充分研究,特别是在早期缩方面.
研究的目的:
- 在阿尔茨海默氏病的早期和晚期研究下丘脑缩.
- 检查下丘脑的结构共变性模式与AD病理学和遗传因素相关.
主要方法:
- 在175名参与者 (CN,MCI,AD) 中使用3TMRI对下丘脑 (HTH) 的半自动体积测量.
- 采用基于声素的形态学 (VBM),皮质厚度 (CTH) 和基于源的形态学 (SBM) 进行结构共变性分析.
- 评估了与诊断组的关联,β-粉样蛋白 (AB) 阳性和阿波利波蛋白E (APOE) ε4状态.
主要成果:
- 在不同疾病阶段观察到的下丘脑缩:下丘脑体积 (HV) CN > MCI > AD.
- HV与AD脆弱区域 (帕佩兹电路,自主调节区域) 有积极的关联.
- 在APOE ε4载体中较强的缩;在生物标志物阳性个体中趋向于更大的缩.
结论:
- 在阿尔茨海默病中,下丘脑的早期结构变化发生在阿尔茨海默病中.
- 脑下垂体体积与AD易受伤害的区域区域体积有覆盖性差异,这表明二次缩.
- 这些发现支持下丘脑在AD的神经退行性级联中的作用.
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