通过在β-cyclodextrin Pickering乳液中的二甲酸甘油提高了环烯的溶解性和生物可用性
Zhongbo Liu1, Yee Ying Lee2, Chin Ping Tan3
1JNU-UPM International Joint Laboratory on Plant Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Food chemistry
|October 15, 2024
概括
使用β-cyclodextrin (β-CD) 和莲油二甲酸甘油 (DAG) 乳液,提高了环烯 (CLs) 的溶解性和生物利用性. 这种配方可以改善CLs.
科学领域:
- 食品科学 食品科学 食品科学
- 制药科学 制药科学
- 生物化学 生物化学
背景情况:
- 环氨基 (CLs) 具有抗炎症,抗骨质疏松和抗瘤的特性.
- CLs的有限水和油溶性阻碍了它们的实际应用.
- 开发有效的传递系统对于增强CL的治疗潜力至关重要.
研究的目的:
- 用不同的油相来配制和描述载有CLs的β-cyclodextrin (β-CD) 稳定乳液.
- 评估通过这些乳液输送的CLs的体外消化性,细胞吸收和抗炎作用.
- 确定最佳的油相,以提高CLs的溶解性和生物可用性.
主要方法:
- 制备含有CLs的β-CD乳液,具有不同的油相,包括驼油二甲基甘油 (DAG).
- 乳液性质的表征,如颗粒大小,物理稳定性和体外可消化性.
- 使用Caco-2细胞模型评估细胞吸收,并通过测量氧化 (NO) 抑制来评估抗炎作用.
- 与油中的CLs相比,CLs的生物利用率的确定.
主要成果:
- 香油DAG因其高极性而显示出CLs的优越溶解能力.
- β-CD与DAG形成了包含复合物,导致颗粒尺寸较小的乳液和增强的物理稳定性.
- 基于DAG的乳液在体外可消化性增加,与油中的CL相比,CL的生物可用性提高了13.6倍.
- 载有CLs的皮克林乳液消化剂显示出显著的氧化 (NO) 抑制 (58.62%) 和改善的Caco-2细胞透.
结论:
- 用β-CD和麻油DAG配制的乳液有效地提高了CLs的可溶性和生物利用性.
- 这种配方策略对开发含有CL的功能性食品和制药产品具有重大潜力.
- 改进的输送系统克服了CLs可溶性差的局限性,为其更广泛的治疗用途铺平了道路.
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