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Updated: Jun 10, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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在与癌症相关的纤维细胞中,基质硬度依赖Hippo通路的激活

Gerard Rubí-Sans1, Agata Nyga2, Miguel A Mateos-Timoneda2

  • 1Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.

Biomaterials advances
|October 15, 2024
PubMed
概括

瘤微环境的硬性显著影响癌症相关纤维细胞中的Hippo信号通路,推动瘤生长. 在正常的纤维细胞中没有观察到这种失调,这突显了 stromal 细胞行为中的关键差异.

关键词:
与癌症相关的纤维细胞.河马的路径 河马的路径瘤微环境是一个微环境.雅普塔兹 (YAP-TAZ) 是一个城市.

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