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节点T细胞淋巴瘤从地幔细胞淋巴瘤转化,与爱斯坦-巴尔病毒感染

Paul D Barone^1,2, Wayne Tam³, Julia T Geyer^1,2

¹NewYork-Presbyterian Hospital, New York, New York, USA.

Pathobiology : journal of immunopathology, molecular and cellular biology

|October 15, 2024

概括

这项研究介绍了一个罕见的地幔细胞淋巴瘤 (MCL) 病例,该病例转化为EBV阳性T细胞淋巴瘤,表明B细胞转变为T细胞血统是可能的. 遗传分析证实了两种淋巴瘤的共同克隆起源.

科学领域:

血液学血液学血液学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

膜细胞淋巴瘤 (MCL) 是一种成熟的B细胞瘤.
血液淋巴细胞疾病中的血统切换已被记录,但从B细胞淋巴瘤到T细胞淋巴瘤是罕见的.
与EBV相关的T细胞淋巴瘤是一个独立的实体.

研究的目的:

报告一个极其罕见的MCL病例,其明显的血统切换为EBV阳性T细胞淋巴瘤.
为了研究这种转化背后的分子机制.
为了解淋巴瘤细胞的可塑性做出贡献.

主要方法:

一个55岁的男性患有MCL的案例介绍.
最初的MCL和随后的T细胞淋巴瘤的流细胞计和活检分析.
细胞遗传测试 (CCND1::IGH融合),克隆性测试 (IGH/IGK,TCR) 和下一代测序 (NGS) 用于分子分析.

主要成果:

通过流细胞计和活检 (BCL1阳性) 确认了MCL的初始诊断.
随后的淋巴结活检显示了EBV阳性T细胞淋巴瘤 (BCL1-负).
共享的CCND1::高融合和两种淋巴瘤类型的保存突变,表明从MCL到T细胞淋巴瘤的克隆关系和演变.

结论:

这个案例说明了在淋巴瘤中从成熟的B细胞转变为成熟的T细胞表型的血统转换的可能性.
对于EBV感染对这种血统切换的作用尚不清楚.
降低IGH促进体的调节可能解释了B细胞到T细胞表型转移期间BCL1表达的丧失.

关键词:

这是EBV的EBV.线程交换机线程交换机线程交换机地膜细胞淋巴瘤是什么这是一种T细胞淋巴瘤.转变差异化转变差异化

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