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相关概念视频

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
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胚胎巨细胞在人类胰腺分化过程中支持内分泌承诺.

Adriana Migliorini1, Sabrina Ge2, Michael H Atkins3

  • 1McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.

Cell stem cell
|October 15, 2024
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概括

巨细胞对于胰腺内分泌细胞的发育和生存至关重要. 这项研究揭示了它们在体外 (in vitro) 的支持性作用,表明在糖尿病治疗中的组织工程中的潜在应用.

关键词:
贝塔细胞 贝塔细胞 贝塔细胞人的胰腺发育 人的胰腺发育人类多能干细胞干细胞免疫细胞 免疫细胞小小的岛屿小小的岛屿有机生物有机物再生医学是一种再生医学.单核RNA测序的一个核.组织改造 组织改造组织居民巨细胞.

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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
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科学领域:

  • 发育生物学是发展生物学.
  • 免疫学 免疫学 免疫学
  • 内分泌学 在内分泌学.

背景情况:

  • 胰腺内分泌细胞的发育涉及组织微环境中的复杂相互作用.
  • 包括巨细胞在内的造血细胞存在于正在发育的人类胰腺中,但它们在内分泌发生过程中的具体作用尚不清楚.

研究的目的:

  • 研究造血细胞,特别是巨细胞在人类胰腺内分泌发育中的作用.
  • 在体外模拟巨细胞和内分泌细胞之间的相互作用.

主要方法:

  • 单核RNA测序 (snRNA-seq) 的第二个三个月的人类胰腺,以识别血造细胞群.
  • 使用人类胚胎干细胞衍生的内分泌和巨细胞器官的共同培养系统的开发.

主要成果:

  • 在正在发育的人类胰腺中,snRNA-seq确定了多样化的造血细胞,包括两个不同的巨细胞子集.
  • 共同培养实验表明,巨细胞在体外支持内分泌细胞的分化和活力.
  • 巨细胞在有机体模型中增强了组织移植.

结论:

  • 组织寄居的巨细胞在人类胰腺内分泌细胞的发育和生存中起着支持作用.
  • 这些发现突显了巨细胞在糖尿病组织工程策略中的潜力.
  • 巨细胞与内分泌细胞的相互作用对于胰腺器官生成至关重要.