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Updated: Jun 10, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

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尼古丁胺增强了Treg分化,通过促进Foxp3乙化在免疫性血栓塞缩症

Ju Li1, Cheng Zhang1, Yuefen Hu1

  • 1Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

British journal of haematology
|October 15, 2024
PubMed
概括

尼古丁胺胺 (NAM) 补充剂通过增强调控性T细胞 (Tregs) 来改善免疫血栓缩 (ITP) 的免疫平衡. 这种NAD+前体通过恢复免疫平衡来显示ITP的治疗潜力.

关键词:
在Sirtuin1中使用.免疫性血小板减少症.尼古丁胺胺是什么 尼古丁胺胺是什么尼古丁胺胺腺因二核酸是什么监管性T细胞监管性T细胞

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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