早期类风湿性关节炎中与上肢相关的残疾 - 长期病程和疾病变量影响:一个队列研究
Maria Rydholm1, Sofia Hagel2, Lennart T H Jacobsson3
1M. Rydholm, OT, C. Turesson, MD, PhD, Rheumatology, Department of Clinical Sciences, Malmö, Lund University, and Department of Rheumatology, Skåne University Hospital, Malmö.
The Journal of rheumatology
|October 15, 2024
概括
在早期类风湿性关节炎 (RA) 中,上肢 (UE) 的残疾最初会改善,但在两年后会恶化. 疼痛和握力在整个研究过程中显著影响UE功能.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 整形外科 整形外科 整形外科
背景情况:
- 早期类风湿性关节炎 (RA) 显著影响上肢 (UE) 功能.
- 了解UE残疾的发展轨迹对于有效管理至关重要.
研究的目的:
- 调查早期RA中UE残疾的纵向过程.
- 检查UE残疾和临床因素之间的相关性,包括握力.
主要方法:
- 一项对222名早期RA患者进行的为期10年的初始队列研究.
- 通过健康评估问卷-残疾指数 (HAQ-DI-UE) 评估的UE残疾.
- 纵向测量握力和临床变量;使用多变量回归分析.
主要成果:
- UE残疾 (HAQ-DI-UE) 在6个月内改善,但在2年后恶化.
- 在HAQ-DI-UE和握力,患者的整体评估和疼痛之间观察到强烈的相关性.
- 收录时的手腕突炎和柔软关节,以及6个月后的肩膀/手腕柔软,独立地影响了UE残疾.
结论:
- 在早期RA中,UE残疾显示出最初的改善,随后的增加.
- 疼痛和手部功能受损是早期RA中UE残疾的关键决定因素.
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