库伊-杰林囊通过调节炎症和肠道微生物群来抑制性结肠炎
Kun Li1, Lengqiu Guo2, Jinghua Yu3
1Department of Gastroenterology, Haian Hospital of Traditional Chinese Medicine, Nantong, China.
Journal of gastroenterology and hepatology
|October 15, 2024
概括
库伊-杰-林囊通过减少炎症和恢复肠道健康,有效治疗性结肠炎 (UC). 结合Kui-Jie-Ling和阿达利穆马布,可以改善UC治疗.
科学领域:
- 胃肠道学和免疫学
- 药理学和治疗学 药理学和治疗学
- 微生物组研究 微生物组研究
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病.
- 库伊-杰-林是一种用于治疗UC的中国医院制剂.
- 阿达利穆马布是一种适度至重度UC的生物疗法.
研究的目的:
- 评估Kui-Jie-Ling对小鼠中硫酸 (DSS) 诱导的UC的保护作用.
- 为了研究Kui-Jie-Ling与阿达利穆马布联合对UC的协同效应.
- 为了阐明库伊-杰-林在缓解UC的潜在机制.
主要方法:
- 使用了网络药理学和动物实验的组合.
- 使用2.5%的DSS溶液建立了UC的动物模型.
- 小鼠接受了Kui-Jie-Ling,阿达利穆马布或组合治疗.
- 分析的关键参数包括疾病活动指数,结肠长度,炎症性细胞因子,短链脂肪酸和肠道微生物群组成.
- 便微生物群移植被用来验证肠道微生物群的作用.
主要成果:
- 库伊-杰-林在缓解UC方面证明了多途径的有效性.
- 治疗抑制了中性粒细胞外细胞陷 (NET) 的形成.
- 它通过LPS-TLR4/NF-κB和IL-23/JAK2/STAT3信号通路调节炎症因素.
- 肠道平衡得到恢复,肠道微生物群的组成得到调节.
结论:
- 这项研究为库伊-杰-林在UC的临床使用提供了实验基础.
- 与Kui-Jie-Ling和adalimumab的联合治疗显示出UC治疗的潜力.
- 这些发现强调了在UC管理中准炎症和肠道微生物群的重要性.
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