化学传感阵列中的时间逆转对称性破裂揭示了消散增强合作传感的一般机制
David Hathcock1, Qiwei Yu1,2, Yuhai Tu3
1IBM T. J. Watson Research Center, Yorktown Heights, USA.
Nature communications
|October 15, 2024
概括
这项研究模拟了大肠杆菌的化学传感阵列,揭示了合作相互作用和能量分散反应如何为敏感信号检测创造不对称的切换动态. 这解释了细菌的适应性感知.
科学领域:
- 生物物理学的生物物理.
- 系统生物学 系统生物学
- 微生物生理学 微生物生理学
背景情况:
- 大肠杆菌使用广泛的化学受体阵列来协作和自适应地感知细胞外信号.
- 化学反应信号涉及histidine kinase CheA和响应调节器CheY,合作性和消散性是关键的,但单独研究的方面.
- 单细胞FRET测量显示了化学传感阵列中激酶活性自发,不对称的切换,表明时间逆向对称性破裂.
研究的目的:
- 开发一个不平衡格子模型,解释在大肠杆菌化学传感阵列中观察到的不对称切换动态.
- 研究细菌化学反应中消散反应和合作合之间的相互作用.
- 为理解具有散散子单元的生物复合体提供一个框架.
主要方法:
- 为细菌化学传感阵列开发一个不平衡格子模型.
- 分析模型以解释基于合作合和散射反应的不对称切换动态.
- 微观检查底层的不可逆转的过渡路径切换时间不对称.
主要成果:
- 该模型表明,不对称的切换动态源于个体消散反应和合作合之间的相互作用.
- 微观分析显示,不可逆转的过渡路径是切换时间不对称的来源.
- 强烈的散射被证明可以通过减轻速度敏感性的权衡来提高信号灵敏度和速度.
结论:
- 消散和合作的相互作用对于解释细菌化学反应中观察到的不对称动态至关重要.
- 开发的模型为研究由消散循环驱动的合生物子单元提供了一个一般框架.
- 未来的单细胞实验可以验证模型关于散射在信号传输中的作用的预测.
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