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在相对较瘦的中国成年人中进行的蛋白质基因组分析确定了影响一般和中央脂肪水平的蛋白质和途径

Andri Iona¹, Pang Yao¹, Alfred Pozarickij¹

¹Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Communications biology

|October 15, 2024

概括

这项研究研究了不同体脂的测量与中国和欧洲成年人的血液蛋白质的关系. 特定的身体脂肪特征,如腰部和部的比率,与许多蛋白质有关,这表明肥胖症治疗的新目标.

科学领域:

遗传学遗传学是一种遗传学.
代谢学代谢学代谢学
生物标志物发现发现

背景情况:

肥胖是已知的疾病风险因素,但其与特定蛋白质生物标志物的因果关系尚不清楚.
了解这些联系对于开发针对肥胖和相关疾病的有针对性的干预措施至关重要.

研究的目的:

系统地调查一般和中心脂肪度测量和血蛋白之间的因果关系.
确定与脂肪相关的新型蛋白质生物标记物和潜在的治疗标.

主要方法:

在东亚和欧洲队列中使用了两样本的门德尔随机化 (MR) 分析.
研究了基因预测的身体质量指数 (BMI),身体脂肪百分比 (BF%),腰围 (WC) 和腰与部比 (WHR) 与2923种血蛋白之间的关联.
从全基因组关联研究 (GWAS) 中使用的cis-protein定量特征位点 (cis-pQTLs).

主要成果:

基因预测的BMI,BF%,WC和WHR与数百种血蛋白显著相关.
在调整其他脂肪性特征后,腰部至部比 (WHR) 显示了最多的蛋白质关联.
七种特定蛋白质在不同的MR分析和种群中与脂肪度量有着强有力的联系.

结论:

肥胖的特征与广泛的血蛋白因果相关.
确定了特定的蛋白质 (例如补充因子B,纤维素) 作为肥胖相关疾病的潜在媒介或点.
这些发现为导致肥胖和相关病理的分子机制提供了新的见解.

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