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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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In any system of units, the units for some physical quantities must be specified through a measurement process. These measurements are the base quantities of the system, and their units are the base units of the system. The algebraic combinations of the base values can then be used to express all other physical quantities. Each of these physical quantities is then referred to as a derived quantity, with each unit being referred to as a derived unit.
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概括
此摘要是机器生成的。

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科学领域:

  • 生物技术是生物技术.
  • 遗传学 是一个遗传学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 基编辑为治疗罕见疾病提供精确的单核酸转换.
  • 目前的基础编辑器设计是劳动密集型的,结果不可预测,精度和效率有限.
  • 尽量减少旁观者突变对于基础编辑的临床应用至关重要.

研究的目的:

  • 开发一个全面和可访问的数据集,以改进基础编辑的计算模型.
  • 创建BE-dataHIVE,一个包含广泛的gRNA目标组合和相关特征的mySQL数据库.
  • 为了促进准确和高效的基础编辑技术的进步.

主要方法:

  • 从五项研究中汇编数据,创建一个大规模的数据集.
  • 整合融温度和能量术语以丰富数据.
  • 计算和结构化的多重数据格式,适合机器学习应用.
  • 开发了一个mySQL数据库 (BE-dataHIVE),包含超过46万个gRNA目标组合.

主要成果:

  • BE-dataHIVE提供了一个强大的数据集,超过46万个gRNA目标组合.
  • 数据库包括丰富的功能,如融温度和能量术语.
  • 预先计算了多个准备用于机器学习的数据结构,并可用.
  • 该数据库可以通过网站和API访问.

结论:

  • BE-dataHIVE解决了在数据库编辑研究中对大型,功能丰富的数据集的关键需求.
  • 该数据库增强了用于预测数据库编辑结果的计算模型的开发和性能.
  • BE-dataHIVE支持从业者和机器学习研究人员在推进基因编辑技术方面.