产前酒精暴露和与身体尺寸,形态障碍和神经发育的关联:系统性审查和元分析
Lisa K Akison1, Nicole Hayes2, Chelsea Vanderpeet3
1School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, Australia.
BMC medicine
|October 15, 2024
概括
这次审查发现产前酒精暴露 (PAE) 与胎儿酒精谱系障碍 (FASD) 的身体尺寸和面部特征有关. 需要更多的研究来确认与其他诊断标准的联系.
科学领域:
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 胎儿酒精谱系障碍 (FASD) 在全球范围内构成了重大公共卫生挑战.
- 目前对FASD的诊断标准缺乏国际共识和强有力的证据基础.
- 这一系统性审查解决了对证据的需求,以告知诊断标准的发展.
研究的目的:
- 系统地审查有关产前酒精暴露 (PAE) 和用于FASD诊断评估的结果之间的联系的证据.
- 为改善和标准化FASD诊断标准提供一个证据基础.
主要方法:
- 对六个数据库进行了系统审查 (开始到2023年2月).
- 包括的研究是检查PAE和诊断领域 (身体尺寸,形状障碍,神经发育,大脑结构) 的病例控制或队列研究.
- 使用随机效应元分析来确定关联,使用GRADE评估证据确定性.
主要成果:
- 在PAE和减少头周长和身体尺寸之间观察到剂量反应关系,特别是在出生时.
- 较高的PAE水平与特征性的哨兵面部形学和几个神经发育结果有关.
- 对于非哨兵性形特征,社会认知,言语,神经疾病和大脑异常存在证据差距.
结论:
- 该审查提供了关于FASD诊断标准的关键组件的指导,强调剂量-反应关系.
- 证据中的重大差距需要未来的研究,特别是精心设计的妊娠队列研究.
- 未来的研究应该集中在PAE对形学,神经发育和大脑结构的影响上.
关键词:
出生的体重出生时的体重.诊断标准 诊断标准 诊断标准形态变异学 (Dysmorphology) 是一种关于形态变异的学科.这就是 FASD 的原因.面部特征 面部特征 面部特征胎儿酒精谱系障碍 胎儿酒精谱系障碍功能性神经发育 功能性神经发育头部周长 头部周长产前暴露于酒精的情况.更多相关视频
15:27Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
14.7K
19:57The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
8.3K
相关概念视频
01:07Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
01:29Intellectual Disability
44
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
44
01:30Attention-Deficit/Hyperactivity Disorder
47
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
47