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不同表面活性剂和多电解质对人工和细胞膜纳米流通的影响

Urška Zagorc¹, Darja Božič², Vesna Arrigler¹

¹University of Ljubljana, Faculty of Chemistry and Chemical Technology, Chair for Physical Chemistry, SI-1000 Ljubljana, Slovenia.

Molecules (Basel, Switzerland)

|October 16, 2024

概括

像SDS和TX100这样的表面活性剂破坏纳米脂质体和生物膜,释放细胞外颗粒 (EP). 像NaPSS和NaPMA这样的稳定聚电解质不会影响纳米脂质体,这表明粒子组织是膜相互作用的关键.

科学领域:

生物物理学的生物物理.
材料科学材料科学材料科学
细胞生物学细胞生物学

背景情况:

纳米和微尺寸的囊泡结构对于跨多种生物体的细胞间通信至关重要.
了解表面活性剂和多电解质与这些结构的相互作用对于生物和纳米技术应用至关重要.

研究的目的:

研究表面活性剂 (CPC,SDS,TX100) 和多电解质 (NaPSS,NaPMA) 对纳米脂质体的影响.
检查SDS和TX100对红细胞和微藻等生物膜的影响.

主要方法:

使用微热量计和光散射 (测量R_h,I_tot等) 进行脂质体表征. ) 的情况.
使用扫描电子显微镜 (SEM) 和流细胞计 (FCM) 来分析来自生物膜的细胞外颗粒 (EP).

主要成果:

表面活性剂 (CPC,SDS,TX100) 在它们的临界菌根度 (CMCs) 以上破坏了纳米脂质体的稳定,形成了更大的聚合物.
阳离子多电解质 (NaPSS,NaPMA) 并没有改变纳米脂质体的稳定性.
SDS和TX100显著增加了红细胞和微藻的EP,与细胞密度下降相关.

结论:

两性分子需要组织成纳米颗粒才能有效地与细胞膜相互作用,并可能进入细胞膜.
该研究强调了表面活性剂与多电解质在纳米脂质体和生物膜上的差异性影响.

关键词:

细胞间的细胞间通信.药物输送是药物输送的过程.细胞外囊泡中的细胞外囊泡.脂质体是一种脂质体.微热量测量是微热量测量的方法.聚电解质的多元电解质.静态和动态的光散射.表面活性剂是什么表面活性剂是什么

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