机器作为甲福林输送辅助剂的使用:实验和计算研究
Sondes Omrani1,2, Safa Gamoudi3,4, César Viseras5
1Laboratory for the Application of Materials to the Environment, Water and Energy (LR21ES15), Faculty of Sciences of Gafsa, University of Gafsa, Gafsa 2112, Tunisia.
这项研究开发了一种用于药物输送的甲胺和有机粘土复合物. 突尼斯的粘土有效吸附甲胺,显示了控制释放应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 制药科学 制药科学
背景情况:
- 有机粘土复合材料为先进的药物输送系统提供了潜力.
- 甲胺 (MET) 是一种广泛使用的抗糖尿病药物.
- 突尼斯的石粘土为开发新型药物载体提供了机会.
研究的目的:
- 为药物输送准备和描述甲胺和突尼斯有机粘土 (HDTMA-Sm) 的复合物.
- 调查粘土对甲胺的吸附机制和能力.
- 在模拟生理条件下评估复合物的药物释放特征.
主要方法:
- 使用阴离子交换能力,表面积分析,XRD,DSC,XRF和FTIR进行实验性表征.
- 计算分子建模以阐明药物粘土相互作用.
- 吸附异温和动力学研究 (弗朗德利希模型,伪二次动力学).
- 在模拟的胃和肠液中进行体外药物释放研究.
主要成果:
- 纯化 (Sm-Na) 和改性 (HDTMA-Sm) 粘土都有效地吸收了MET,最大负载分别为12.42%和21.97%.
- 吸附遵循弗洛伊德利希模型和伪二阶动力学,表明异质吸附.
- 分子建模证实了阴离子交换是MET/HDTMA-Sm.的主要吸附机制.
- 释放研究表明,有潜力控制药物输送.
结论:
- 突尼斯有机粘土 (HDTMA-Sm) 和净化粘土 (Sm-Na) 是甲胺的有效载体.
- 复合材料对控制药物输送的未来临床应用有希望.
- 结合实验和计算方法,可以全面了解药物输送系统.
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