开发和评估一个具有成本效益的,基于碳的,延长释放的Febuxostat平板电脑
Israa Hamid Al-Ani1, Mohammad Hailat2, Dina J Mohammed1
1Faculty of Pharmacy, PDRC, Al-Ahliyya Amman University, Amman 19328, Jordan.
Molecules (Basel, Switzerland)
|October 16, 2024
概括
这项研究开发了使用活性炭的延长释放型febuxostat (FEB) 片,改善了药物释放和患者的服药性. 这种新配方提供了一个具有成本效益的,可控的输送解决方案,具有增强的生物可用性.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 费布克索斯塔特 (Febuxostat,FEB) 是一种BCSII类药物,具有较差的溶解性和高的脂性,使口服配方的开发复杂化.
- 由于药物释放速度快,现有的配方可能无法提供最佳的治疗特征或患者服药.
- 控制释放药物递送的目的是提高疗效和减少剂量频率.
研究的目的:
- 为了开发一个具有成本效益的延长释放的febuxostat片剂配方.
- 使用活性炭作为吸附剂来修改febuxostat释放特征.
- 评估开发的配方的物理,体外和体内性能.
主要方法:
- 八种不同的febuxostat与木炭比率的配方.
- 使用富里埃变换红外光谱法 (FTIR) 和差分扫描热量计 (DSC) 进行了表征.
- 在体外释放药物的研究遵循美国药典 (USP) 标准.
- 在体内药理动力学研究比较延长释放和立即释放片.
主要成果:
- 最佳配方 (1:0.25 FEB与木炭的比率) 实现了一致的12小时零级药物释放特征.
- 物理相互作用研究 (FTIR,DSC) 证实了兼容性.
- 在体内研究表明,对于febuxostat,血度-时间概况显著延长.
- 优化的平板电脑符合USP硬度和分解标准.
结论:
- 活性炭有效地增强了febuxostat的受控释放.
- 开发的延长释放费布克索斯塔特片提供了改善的生物可用性和患者遵守.
- 这种配方为febuxostat输送提供了一种具有成本效益和前景的方法.
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