视网膜微血管变化与COVID-19后的执行功能障碍有关
Mar Ariza1,2, Barbara Delas3, Beatriz Rodriguez3
1Grup de Recerca en Cervell, Cognició i Conducta, Consorci Sanitari de Terrassa (CST)-Hospital Universitari, 08227 Terrassa, Spain.
Journal of clinical medicine
|October 16, 2024
概括
患有严重COVID-19病史的COVID-19后病情 (PCC) 患者表现出视网膜血管密度降低和较大的状血管区域,与认知缺陷有关. 这些发现突显了持续的微血管损伤,影响了视网膜和大脑的健康.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 血管生物学 血管生物学
背景情况:
- 之前的研究表明,在COVID-19幸存者中,视网膜血管密度 (VD) 降低,叶血管区域 (FAZ) 扩大.
- COVID-19的严重程度与这些视网膜微血管变化的程度相关.
研究的目的:
- 在COVID-19后病情 (PCC) 患者中调查视网膜微血管化.
- 根据COVID-19的严重程度,将这些微血管变化与认知表现相关联.
主要方法:
- 在104名PCC参与者 (严重与轻度COVID-19病史) 的观测横截面研究.
- 光学连贯断层扫描血管造影 (OCTA) 用于测量视网膜VD, perfusion密度 (PD) 和FAZ.
- 对所有参与者进行认知评估.
主要成果:
- 与轻度病例相比,严重的PCC病例表现出明显较低的中央和总VD,较低的中央PD,以及较大的FAZ区域和周边.
- 严重的病例也显示出更大的认知障碍,特别是在处理速度和执行功能方面.
- 减少的VD,减少的PD和更大的FAZ与PCC样本中的更差的执行功能有关.
结论:
- 视网膜微血管变化 (减少VD/PD,增加FAZ) 与PCC的认知障碍有关.
- 严重的COVID-19似乎会导致持续的微血管损伤,影响视网膜和认知健康.
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