想象多发性硬化症患者的旅程:一个症状概述
Inês Correia1,2, Catarina Bernardes1, Carolina Cunha1
1Neurology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, 3004-561 Coimbra, Portugal.
Journal of clinical medicine
|October 16, 2024
概括
现代多发性硬化症 (MS) 患者表现出各种症状,包括感官问题,疲劳和失衡,根据疾病阶段和形式而异. 早期诊断和治疗影响了MS症状的自然史.
科学领域:
- 神经学 神经学
- 临床研究 临床研究
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 症状在历史上是基于老年患者队列.
- 现代MS诊断和治疗改变了疾病的自然史和症状表现.
- 了解当代多发性硬化症的症状对于有效的患者管理至关重要.
研究的目的:
- 评估现代多发性硬化症患者队列所经历的临床症状.
- 分析不同疾病阶段的症状患病率:诊断前,诊断,疾病过程和当前状态.
- 为了比较多发性硬化症不同亚型 (RRMS,SPMS,PPMS) 的症状概况.
主要方法:
- 具有回顾性和横截面元素的观察性研究.
- 符合2017年修订的麦当劳MS标准的163名患者完成了一项调查.
- 收集的数据包括人口统计信息和详细的临床症状.
主要成果:
- 诊断前:74.2%的人经历了症状,主要是感官问题,疲劳和失衡.
- 诊断时:感觉 (46.6%) 和运动 (36.8%) 投诉是最常见的.
- 症状模式因多发性硬化症亚型而异:RRMS/SPMS (感觉,运动,失衡),PPMS (运动,失衡,尿生殖). 渐进的形式显示出更高的疲劳和运动症状.
结论:
- 这项研究描述了当代患者群体中多发性硬化症症状的当前范围.
- 这些发现与之前的研究一致,证实了整个疾病过程中持续的症状.
- 在复发性复发和渐进性MS形式之间,症状呈现有显著差异.
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