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酒精相关性肝炎的细菌感染特征:对2016-2021年队列的审查
Cesar Jiménez1,2, Aina Martí-Carretero1, Ares Villagrasa1,3
1Liver Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain.
Journal of clinical medicine
|October 16, 2024
概括
在酒精相关性肝炎 (AH) 患者中,细菌感染很常见,导致严重的并发症,如急性至慢性肝衰竭 (ACLF) 和死亡率增加,特别是在医院感染的情况下. 早期诊断和在入院时治疗感染改善了生存结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 细菌感染 (BI) 对与酒精相关的肝炎 (AH) 的死亡率有显著的贡献.
- 最近关于AH患者BI的研究是有限的,需要更新数据.
- 了解BI的特征和结果对于管理AH患者至关重要.
研究的目的:
- 评估酒精相关肝炎患者细菌感染的发病率,特征和结果.
- 为了比较感染和非感染的AH患者之间的并发症和死亡率.
- 评估住院感染与入院感染对患者结果的影响.
主要方法:
- 在2016-2021年期间入院的AH患者的观察性描述性研究.
- 收集临床和微生物学数据.
- 感染群与非感染群之间的并发症 (包括ACLF) 和90天死亡率的比较.
主要成果:
- 细菌感染发生在38.2%的AH患者90天,胸部感染是最常见的.
- 受感染的患者有较高的肝衰减率,ACLF和较低的存活率 (81.8%与95.8%相比).
- 与入院感染 (93.3%) 相比,住院感染与明显更差的存活率 (72.7%) 相关.
结论:
- 在与酒精有关的肝炎中,细菌感染是常见的,具有重大风险.
- 住院感染与严重并发症有关,包括高水平的ACLF和死亡率.
- 住院时诊断的感染的及时治疗没有对存活率产生负面影响.
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