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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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在基底细胞癌的免疫治疗.

Loredana Ungureanu1,2, Alina Florentina Vasilovici1,2, Salomea-Ruth Halmágyi2,3

  • 1Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

Journal of clinical medicine
|October 16, 2024
PubMed
概括

基础细胞癌 (BCC) 治疗包括局部伊米奎莫德用于低风险病例,显示高清除,但更多的副作用. 先进的BCC可能会从全身免疫疗法中受益,尽管结果各不相同.

关键词:
基底细胞癌的癌症.检查点抑制剂检查点抑制剂像素的方法 像素的方法免疫疗法 免疫疗法

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科学领域:

  • 在瘤学瘤学.
  • 皮肤病学 皮肤病学
  • 免疫学 免疫学 免疫学

背景情况:

  • 基底细胞癌 (BCC) 是最常见的癌症,发病率正在上升.
  • 标准治疗是手术切除,但对于特定的BCC类型存在替代方案.
  • 先进的,不可切割的或转移的BCC可能需要全身治疗,如刺抑制剂和免疫治疗.

研究的目的:

  • 审查局部和全身免疫疗法的有效性,以控制BCC.
  • 要突出伊米基莫德和其他局部免疫调节剂的作用.
  • 评估系统性免疫疗法的有效性,包括PD-L1抑制剂,在先进的BCC.

主要方法:

  • 对BCC的局部和全身免疫疗法的现有文献的审查.
  • 对评估伊米基莫德,干扰素和介质素-2的研究进行分析.
  • 对高级BCC中编程死亡配体1 (PD-L1) 抑制剂的结果的检查.

主要成果:

  • 伊米基莫德在表面和低风险结节BCC的组织学清除率高,但与更多不良事件有关.
  • 像伊米基莫德这样的局部疗法可以单独使用或作为莫斯手术等手术的辅助剂,其中一些结果与手术结果相似.
  • 系统性PD-L1抑制剂在晚期BCC中表现出可变的疗效,特别是在进展或不耐受 hedgehog路径抑制剂 (HHI) 的患者中.

结论:

  • 局部免疫疗法,特别是伊米基莫德,为特定的BCC类型提供治疗选择,平衡疗效和耐受性.
  • 系统性免疫疗法代表了先进的BCC的不断发展的治疗方式,目前正在研究优化其使用.
  • 需要进一步的研究,以充分阐明各种免疫治疗策略在BCC管理中的作用和最佳应用.