影响活体捐赠者肝移植期间手术内输血要求的因素
Hakan Kilercik1, Sami Akbulut2,3, Ahmed Elsarawy3
1Department of Anesthesiology and Reanimation, Gaziosmanpasa Hospital, Faculty of Medicine, Istanbul Yeni Yuzyil University, 34010 Istanbul, Turkey.
Journal of clinical medicine
|October 16, 2024
概括
肝移植期间的手术内输血与较差的结果有关. 移植前的血红蛋白,白蛋白和纤维蛋白水平可以预测肝移植接受者的输血需要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植手术 移植手术
- 麻醉学 麻醉学
背景情况:
- 肝移植 (LT) 期间的手术内输血 (IOBT) 与患者的负面结果有关.
- 很大一部分的LT手术可能不需要IOBT,但活体供体肝移植 (LDLT) 的预测因素仍然不清楚.
- 这项研究调查了成年右叶片LDLT的一致队列中的IOBT预测因子.
研究的目的:
- 确定成年右叶LDLT中IOBT的移植前预测因子.
- 探索IOBT和LDLT后一年的整体存活率之间的关联.
- 使用血清生物标志物建立IOBT的预测截止值.
主要方法:
- 从成年LDLT接受者的前性收集数据的回顾性分析 (2018年1月 - 2023年10月).
- 使用单变量和多变量分析,比较接受IOBT和未接受IOBT的患者.
- 接收器操作特征 (ROC) 曲线分析用于预测器切断和Kaplan-Meier方法用于生存分析.
主要成果:
- 与IOBT组 (n=163) 相比,没有IOBT组 (n=56) 的手术前血红蛋白,纤维素和白蛋白水平较高.
- 在没有IOBT组中观察到,移植前腹部上部手术,门静脉血栓,肝综合征和炎的发病率较低.
- 移植前的血红蛋白 (≤11.5),纤维素 (≤125) 和白蛋白 (≤3.6) 是IOBT的独立预测因子,无IOBT与更高的一年生存率 (100%与83%相比) 相关.
结论:
- 在LDLT期间的IOBT与较差的患者结局有关.
- 血清血红蛋白,白蛋白和纤维素素水平的移植前评估可以预测IOBT的必要性.
- 优化移植前生物标志物可能会减少IOBT并改善肝移植结果.
相关概念视频
Kidney Transplant I: Introduction
2
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
2
Kidney Transplant II: Surgical Procedure
2
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
2
Blood Transfusion
525
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
525
Kidney Transplant III: Nursing Management
3
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
3
Blood Transfusion and Agglutination
10.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.7K


