患有局部和广泛慢性疼痛的老年波兰人的炎症 - 来自基于人口的PolSenior研究的结果
Anna Chudek1, Przemysław Kotyla2, Elżbieta Kozak-Szkopek3,4
1Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.
Journal of clinical medicine
|October 16, 2024
概括
显著的炎症增加了老年人广泛的慢性疼痛 (CWP). 女性和患有抑郁症的人更容易患CWP,而营养不良与区域慢性疼痛 (CRegP) 有关.
科学领域:
- 老年学是一门学科.
- 疼痛医学 医学 疼痛医学
- 炎症研究 炎症研究
背景情况:
- 炎症降低疼痛值,并使恶性感受器敏感.
- 炎症对老年人的区域性 (CRegP) 和广泛的慢性疼痛 (CWP) 的影响仍然不清楚.
- 本研究调查了老年人群中CRegP和CWP的患病率以及相关因素.
研究的目的:
- 为了确定老年人中CRegP和CWP的流行率.
- 确定与CRegP和CWP相关的因素.
- 探索老年人的炎症状态和慢性疼痛之间的关系.
主要方法:
- 利用了波兰全国范围的PolSenior研究的数据,不包括患有严重痴呆症的个人.
- 评估了10个身体区域的疼痛发生情况,以定义CRegP和CWP.
- 根据C-反应蛋白 (CRP) 和IN-6 (IL-6) 水平,将参与者分类为没有,轻度或显著的炎症.
主要成果:
- CRegP比CWP (8.8%) 更为普遍 (33.9%).
- 与轻度或没有炎症 (8.4%) 相比,患有严重炎症 (11.4%) 的个体更常见的是广泛的慢性疼痛 (CWP).
- 与CWP相关的因素包括女性性别 (OR 3.67) 和严重抑郁症症状 (OR 2.85);营养不良与CRegP有关 (OR 2.00).
结论:
- 显著的炎症与老年人中CWP的发病率较高有关.
- 女性性别和严重抑郁症是CWP的关键预测因素.
- 营养不良是该人口中与CRegP相关的最重要因素.
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