代谢综合征的系统审查:关键相关病理和非侵入性诊断方法
Francesco Giangregorio1, Emilio Mosconi1, Maria Grazia Debellis1
1Department of Internal Medicine, Codogno Hospital, Via Marconi 1, 26900 Codogno, Italy.
Journal of clinical medicine
|October 16, 2024
概括
代谢综合征 (MetS) 是一种系统性疾病,与许多健康问题有关,包括心血管疾病. 非侵入性肝脏评估可以帮助评估MetS严重程度和相关的心血管风险.
科学领域:
- 内部医学 内部医学
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 代谢综合征 (MetS) 涉及中央肥胖症,胰岛素耐药性,高血压和脂质失调症,通常源自肝脏脂肪.
- 肝硬化会引发炎症和纤维化,增加2型糖尿病 (T2DM) 和心血管疾病 (CVD) 的风险.
- 甲状腺硬化与T2DM (5-7倍),心血管疾病 (3倍) 和全因死亡率 (1.5倍) 的显著增加风险有关.
研究的目的:
- 审查代谢综合征作为一种全身性疾病及其与主要内科疾病的相互作用.
- 突出一个整体方法对管理MTS的从业人员的重要性.
- 讨论评估MetS及其肝脏表现的非侵入性工具.
主要方法:
- 进行了详尽的PubMed搜索,直到2024年7月,使用了MetS和相关病理的术语.
- 包括英语的人类研究,评估MetS和肝纤维化/胆固醇症的非侵入性技术.
- 选择了300项遵循PRISMA指南的研究,不包括非人类或非英语研究.
主要成果:
- 确定了MetS和各种描述的病理之间明显的相关性.
- 表明非侵入性肝纤维化和脂肪酸的评估可以作为疾病严重程度的标志物.
- 发现MetS与心血管疾病发病率的增加有关,独立于传统的风险因素.
结论:
- 代谢综合征是一种多系统性疾病,影响肝脏以外的多个器官.
- 非侵入性肝纤维化和肥胖症评估有助于评估METS患者的心血管风险.
- 评估肝硬化症为MetS及其并发症,特别是心血管疾病提供了新的诊断,治疗和预后策略.
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