触发器警告:现代饮食,生活方式和环境如何触发自体主导多性病的进展
Melina Messing1, Jacob A Torres1, Nickolas Holznecht1
1Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Nutrients
|October 16, 2024
概括
现代饮食引发慢性病 (CKD) 和其遗传形式,自体主导多囊性病 (ADPKD). 生活方式的改变,如碳水化合物限制,可能会减缓ADPKD的进展.
科学领域:
- 进化生物学是进化的生物学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢研究的研究.
背景情况:
- 慢性病 (CKD) 患病率正在上升,原因是古石器时代适应基因与现代饮食之间的不匹配.
- 标准美国饮食 (SAD) 导致2型糖尿病,炎症和高血压,加剧CKD.
- 自体主导多囊性病 (ADPKD) 通常被视为纯遗传,但环境因素也起着作用.
研究的目的:
- 挑战对ADPKD仅仅是遗传性的宿命主义观点.
- 探索现代饮食,生活方式和环境因素如何影响ADPKD进展.
- 突出保守的,非药理学策略来管理ADPKD.
主要方法:
- 审查关于CKD,ADPKD,进化生物学和营养的现有文献.
- 分析碳水化合物消耗,高血糖和胰岛素抵抗对脏健康的影响.
- 在ADPKD中检查脱水,电解质失衡和肠道失调等因素.
主要成果:
- 现代饮食习惯和生活方式的选择显著影响ADPKD的进展.
- 过度消耗碳水化合物,高血糖和胰岛素抵抗对脏健康有害.
- 碳水化合物限制,基因代谢疗法 (KMT) 和管理石质基因风险都显示出治疗潜力.
结论:
- ADPKD的进展可以受到饮食和生活方式的影响,而不仅仅是遗传.
- 饮食修改和生活方式改变为ADPKD管理提供了可行的,低成本的策略.
- 将饮食和生活方式纳入临床实践对于改善ADPKD患者的治疗结果至关重要.
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