基于血液微量营养素水平的中国老年人睡眠障碍的风险相关模型:一个匹配的病例对照研究
Cheng Cheng1, Xukun Chen1, Liyang Zhang1
1Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Nutrients
|October 16, 2024
概括
患有睡眠障碍的老年人血液中关键微量营养素水平较低. 结合维生素E (VE),叶酸和 (Se) 的模型有效预测了这一群体的睡眠障碍风险.
科学领域:
- 老年学是指老年学的学科.
- 营养科学 营养科学
- 睡眠医学 睡眠医学
背景情况:
- 衰老与身体能力的下降和对微量营养素缺乏的易感性增加有关.
- 微量营养素状况可能会显著影响老年人睡眠质量.
研究的目的:
- 在中国老年人中开发睡眠障碍的风险相关模型.
- 研究血液中微量营养素水平与睡眠障碍之间的关联.
主要方法:
- 一项匹配的病例对照研究,涉及124名睡眠障碍患者和124名对照患者.
- 干血斑点技术用于测量全血微量营养素水平.
- 接收器操作特征 (ROC) 曲线和名ogram模型,用于评估诊断和预测能力.
主要成果:
- 睡眠障碍患者的维生素A,维生素E (VE),叶酸,,铜,铁和 (Se) 含量较低.
- 对于睡眠障碍,VE,叶酸和Se的组合显示出高的诊断准确性 (曲线下的面积=0.964).
- 一个整合VE,叶酸和Se的诺莫格拉姆模型在评估睡眠障碍风险时显示出良好的一致性 (0.88).
结论:
- 基于血液VE,叶酸和Se水平的风险相关模型显示,对评估老年人睡眠障碍风险有希望.
- 微量营养素状况,特别是VE,叶酸和Se,是老年人睡眠障碍的一个重要因素.
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