口服三糖摄入调节微生物群-肠-大脑轴,并在同核蛋白病症小鼠模型中具有神经保护作用
Solène Pradeloux1,2, Katherine Coulombe1,2, Alexandre Jules Kennang Ouamba1,3
1Centre de Recherche du CHU de Québec, Québec, QC G1V 4G2, Canada.
Nutrients
|October 16, 2024
概括
在帕金森病的小鼠模型中,trehalose通过调节肠道微生物群和增加GLP-1来显示神经保护作用. 这些发现表明,三糖可能是帕金森病 (PD) 的潜在治疗剂.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,影响大脑和肠道中的多巴胺基神经元.
- 肠道微生物群失生症越来越多地被认为是PD病变发生的一个因素.
- 肠道吸收不良的糖类特雷哈洛斯 (Trehalose) 被研究其潜在的肠道介导的神经保护作用.
研究的目的:
- 在帕金森病的小鼠模型中研究三糖的神经保护作用.
- 为了确定三糖是否调节肠道微生物群的组成和功能.
- 评估三糖对葡萄糖类1 (GLP-1) 分泌的影响.
主要方法:
- 使用了一种转基因小鼠模型 (PrP-A53T G2-3) 过度表达人类α-synuclein.
- 在饮用水中服用三糖,麦芽糖或糖糖 (2% w/v) 6.5个月.
- 评估了氨酸氧酶免疫活性,肠道微生物群多样性和GLP-1水平.
主要成果:
- 特雷霍洛斯在PD小鼠的黑质体,条纹体和肠道中阻止了氨酸氧酶的减少.
- 醇调节肠道微生物群,保持多样性并促进有益的细菌.
- 特雷哈洛斯治疗增加了29%的肠道GLP-1分泌.
结论:
- 在帕金森病模型中,醇具有神经保护作用,可能通过肠道微生物群调节和增加GLP-1分泌而间接介导.
- 与产生葡萄糖的糖类 (马尔托斯,糖) 不同,三糖证明了它的有效性,这表明它的作用与葡萄糖无关.
- 醇代表了针对肠-大脑轴的帕金森病的潜在治疗策略.
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