塔拉克萨蒙古多糖类通过激活AKT/mTOR通路来逆转小鼠的肥胖
Xiaoyu Yue1, Shilong Yu1, Yue Luan1
1State Key Laboratory of Animal Biotech Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Nutrients
|October 16, 2024
概括
食Taraxacum mongolicum多糖 (TMPs) 在高脂肪饮食的小鼠中显著降低了体重增加和改善了脂质配置文件. TMPs通过激活AKT/mTOR途径来调节肥胖,从而促进脂肪的化.
科学领域:
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
- 代谢研究研究 代谢研究
背景情况:
- 肥胖是一个严重并发症的全球健康问题.
- 植物多糖体显示出有希望的药理学益处.
- 研究Taraxacum mongolicum多糖 (TMPs) 对于肥胖的调节.
研究的目的:
- 阐明TMPs在肥胖和脂肪色中的机制.
- 评估TMPs对脂质代谢的影响.
- 确定TMPs对AKT/mTOR通路的影响.
主要方法:
- 在C57BL/6J小鼠中,高脂肪饮食 (HFD) 诱导肥胖模型.
- 在10周内补充0.3%的TMP.
- 分析身体体重,食物摄入量,血清脂质,组织组织学和AKT/mTOR通路蛋白质的西部斑.
主要成果:
- 与HFD组相比,TMP补充剂显著减少了体重增加.
- TMPs降低了血清总胆固醇,甘油三和LDL胆固醇.
- 组织学分析显示,脂肪组织和肝脏中的脂质沉积减少.
结论:
- TMPs对脂质代谢产生有益影响.
- TMPs增加了酸化AKT和mTOR的表达.
- AKT/mTOR通路参与了TMPs的抗肥胖作用.
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