平等非生产性状态作为急性心血管栓塞性中风和功能不良结果的独立风险因素
Kotaro Noda1,2, Yorito Hattori3, Hiroaki Murata1
1Department of Neurology, National Cerebral and Cardiovascular Center, 6-1, Kishibe-shimmachi, Suita 564-8565, Japan.
Nutrients
|October 16, 2024
概括
肠道微生物群的Equol产生影响中风风险和结果. 乙醇生产者有较低的心血管血栓性中风风险和更好的康复,这表明其在预防和治疗中风方面的潜力.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 心脏病学 心脏病学
背景情况:
- 肠道微生物群中的代谢物Equol显示出对心血管疾病和痴呆症的保护作用.
- 豆类异黄摄入量并不总是保证这些保护作用,突出了equol生产的作用.
- 产卵状况对脑血管疾病的影响仍未得到充分研究.
研究的目的:
- 为了调查equol生产状态和中风的发展之间的联系.
- 为了确定equol产生的状态和中风后的神经预后之间的关系.
主要方法:
- 追溯性队列研究,比较健康受试者和急性中风患者的equol生产者频率.
- 从2019年9月到2021年10月收集的数据.
- 统计分析包括赔率比率和置信区间来评估关联.
主要成果:
- 在健康受试者和缺血性中风患者之间,equol生产者比例没有显著差异.
- 心血管血栓性中风的患病率显著较低,均生产者的患病率明显较低 (aOR 0.46,p=0.05).
- 同样,非生产者的心房的患病率较高 (27.5%对13.3%,p=0.04) 和左心房体积指数更高的趋势.
- 在放电后,Equol生产商表现出显著有利的功能结果 (aOR 2.84,p=0.02).
结论:
- 产生等的状态与心血管血栓性中风风险降低和神经预后改善有关.
- 埃科尔可能是旨在预防心血管栓塞性中风和改善心房功能的干预措施的有价值的目标.
- 埃科尔在改善因缺血性中风康复的患者的功能结果方面表现有前途.
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