在美国成年人中探索多种痕迹金属与贫血之间的关联和调解因素:NHANES 2017-2020年NHANES的见解
Lijie Xie1, Xinchao Guan1, Yixiang Zhou1
1School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Nutrients
|October 16, 2024
概括
像和这样的微量金属可能会增加贫血风险,而和则提供保护. 这些关联受铁状况和炎症的影响,女性表现出更高的易感性.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 贫血症是一个重大的全球健康挑战.
- 身体中的微量金属水平可能会影响贫血发病率.
研究的目的:
- 调查五种微量金属 (,,,,,) 与贫血风险之间的关联.
- 探索铁的状态和炎症在这些关系中的调解作用.
- 进行性别分层分析,以确定特定性别的敏感性.
主要方法:
- 利用了来自美国1274名成年人的数据,这些数据来自2017-2020年国家健康和营养检查调查 (NHANES).
- 使用后勤回归,量子g计算 (QGC) 和贝叶斯内核机器回归 (BKMR) 来评估金属效应.
- 进行中介分析,以检查铁状况和炎症的影响.
主要成果:
- (Co) 和 (Ni) 与贫血风险增加有关; (Se) 和 (Mn) 显示有保护作用.
- 结合的微量金属混合物与贫血风险有负相关性.
- 女人表现出不太明显的微量金属的保护作用.
- 铁状况和炎症介导了这些关联的10.29%58.18%.
结论:
- 微量元素混合物与降低贫血风险有关,Se是保护性的,Co是危险因素.
- 女性似乎更容易受到微金属对贫血的影响.
- 铁状况和炎症是微量金属和贫血之间关系的重要调解者.
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