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中度和重度COVID-19病例中的DNA损伤:与人口,临床和实验室参数的关系

Tigran Harutyunyan^1,2, Anzhela Sargsyan^1,2, Lily Kalashyan¹

¹Laboratory of General and Molecular Genetics, Research Institute of Biology, Yerevan State University, Alex Manoogian 1, Yerevan 0025, Armenia.

International journal of molecular sciences

|October 16, 2024

概括

在COVID-19患者中,DNA损伤升高,特别是在严重病例和男性中. 这种DNA损伤与危险因素相关,并可能作为疾病严重程度的生物标志物.

科学领域:

遗传学是一个遗传学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

感染SARS-CoV-2可能会导致人类DNA受损.
了解这种损害对于评估COVID-19的进展至关重要.
白细胞DNA损伤被调查为一个潜在的指标.

研究的目的:

为了调查COVID-19患者白细胞中的DNA损伤.
为了将DNA损伤与人口,临床和实验室参数相关联.
评估DNA损伤作为COVID-19严重程度的潜在生物标志物.

主要方法:

从65名COVID-19患者的白细胞中研究了DNA损伤.
根据性别,年龄和疾病严重程度对患者进行分层分类.
与临床参数相关的DNA损伤,并使用ROC分析进行预测.

主要成果:

COVID-19患者的DNA损伤明显高于对照组 (12.44%对5.09%).
严重病例 (14.66%) 和男性 (13.45%) 呈现出比中度病例和女性更大的DNA损伤.
与国际正常化比率 (INR) 和肌素相关的DNA损伤,以及与年龄,CRP和肌素一起预测的严重程度.

结论:

在COVID-19患者中,DNA损伤升高,与疾病严重程度有关.
DNA损伤与已确定的COVID-19风险因素相关.
DNA损伤显示出作为COVID-19严重程度评估的预后生物标志物的潜力.

关键词:

在 COVID-19 疫情中,造成的DNA损伤是DNA损伤.在SARS-CoV-2病毒.彗星测试试验彗星测试试验

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