纠的联系:宫癌中的HIV和HPV相互作用 - - 一个全面的审查
Giuliana Pavone1,2, Andrea Marino3, Viviana Fisicaro4
1Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
International journal of molecular sciences
|October 16, 2024
概括
通过HPV疫苗接种和查,可以预防宫癌 (CC). 由于HIV-HPV共感染,艾滋病毒感染妇女 (WLWH) 面临更高的CC风险,需要定制的预防和管理策略.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 宫癌 (CC) 是一个主要的全球健康问题,与持续的人类乳头瘤病毒 (HPV) 感染密切相关.
- 同时感染人类免疫缺陷病毒 (HIV) 显著增加了CC风险和进展,特别是在艾滋病毒感染女性 (WLWH) 中.
- 与艾滋病毒相关的免疫缺陷增加了对HPV和CC的易感性,使其成为艾滋病定义疾病.
研究的目的:
- 审查艾滋病毒感染妇女 (WLWH) 感染HPV和宫癌 (CC) 的现有证据.
- 突出艾滋病毒和HPV在CC病变发生,预防,诊断和治疗中的复杂相互作用.
主要方法:
- 关于HPV,子宫癌和HIV联合感染的现有研究的文献综述.
- 对影响CC风险和WLWH结果的因素分析.
- 综合了有关预防,诊断和治疗策略的数据.
主要成果:
- HPV是CC的主要原因,疫苗接种/查是预防的关键方法.
- 由于免疫缺陷和查障碍,WLWH具有HPV暴露和CC的风险增加.
- 艾滋病毒和HPV的同时感染可能会加速CC的发展,在WLWH中更早诊断.
- 抗逆转录病毒疗法 (ART) 降低了WLWH中CC风险.
结论:
- 在CC中,HIV和HPV之间的关系是复杂的,双向的.
- 针对性的查,预防和治疗对于WLWH减少CC负担至关重要.
- 需要继续进行研究,以优化WLWH中CC的管理策略.
相关概念视频
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...


