探索药用植物的老化和老化特性,用于抗衰老疗法
Monika Imb1, Zsolt Véghelyi1, Michael Maurer1
1Department of Applied Life Sciences, Bioengineering, University of Applied Sciences Campus Wien, Favoritenstraße 222, 1100 Vienna, Austria.
International journal of molecular sciences
|October 16, 2024
概括
药用植物表现出老化和老态的潜力. 虽然黄金棒和奎尔丁表现出有益的抗衰老作用,但香可能会诱导有害的炎症,影响细胞衰老疗法.
科学领域:
- 细胞和分子生物学 细胞和分子生物学
- 衰老研究研究 衰老研究
- 植物化学 植物化学
背景情况:
- 老化疗法和老化疗法旨在消除衰老细胞,这些细胞与衰老有关.
- 从药用植物中研究天然化合物为温和的抗衰老策略提供了潜在的途径.
- 在健康个体的临床研究中存在挑战,需要替代研究模式.
研究的目的:
- 评价精选药用植物的老化和老化特性:香,金,雷石和绿茶.
- 评估这些植物提取物对细胞衰老标志物和炎症通路的影响.
- 为了比较植物提取物与氨酸 (Quercetin) 的作用,这是已知的老化控制剂.
主要方法:
- 在人类皮肤纤维细胞中,使用etoposide诱导细胞衰老.
- 使用Presto Blue和SA-β-Gal试验测量了解活性.
- 通过IL-6 ELISA和qPCR分析了形效应,以评估与衰老相关的分泌表型 (SASP) 标志物.
主要成果:
- 香提取物诱导了细胞因子水平和SASP标记物的显着增加,这表明一种促炎症的"细胞因子风暴".
- 黄金杆显示出潜在的老化效应,而氨酸则表现出老化特征.
- 所有测试的草药都表现出一些老化能力; 氨酸也表现出老化效应.
结论:
- 药用草本具有老化和老化潜力,为抗衰老疗法提供了可能性.
- 香的炎症抑制作用值得谨慎使用,特别是在与化疗的潜在相互作用方面.
- 了解炎症的双重作用在开发老化和老化干预措施时至关重要.
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