相关实验视频

Updated: Jun 10, 2025

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing
09:59

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing

Published on: October 11, 2021

3.0K

用单细胞RNA测序鉴定局部性硬化皮肤内皮细胞子集群的表征 确定NOTCH信号通路

Theresa Hutchins1, Anwesha Sanyal1, Deren Esencan1

  • 1Department of Pediatrics (Rheumatology), University of Pittsburgh, Pittsburgh, PA 15224, USA.

International journal of molecular sciences
|October 16, 2024
PubMed
概括

局部性硬化症 (LS) 涉及皮肤硬化和纤维化. 这项研究揭示了LS皮肤中患病的内皮细胞促进纤维化,并激活与表皮异常相关的途径,为病原发生提供了新的见解.

关键词:
IL33 IL33 的时间.在IL6 IL6 IL6 IL6 IL6JAG-NOTCH信号发出一个信号.这就是SELE SELE.XIST XIST 这是一个很好的例子.它们是内皮细胞的内皮细胞.局部性硬化皮肤病局部性硬化皮肤病莫菲亚 (Morphea) 是一个形象.一个单细胞RNA测序.皮肤 皮肤 皮肤

更多相关视频

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis07:29

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

Published on: May 16, 2020

6.1K
Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch09:10

Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch

Published on: April 21, 2023

943

相关概念视频

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K